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Mastocytosis Activity Score (MAS)

Mastocytosis Activity Score (MAS)

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This questionnaire for assessing disease activity in patients with cutaneous and indolent systemic mastocytosis is a symptom questionnaire that was specially developed for patients with mastocytosis. The Mastocytosis Activity Score (MAS) is easy to use and has been validated for patients with cutaneous and indolent systemic mastocytosis.

The MAS was developed at Charité by a team led by PD Dr. Frank Siebenhaar, PD Dr. Karsten Weller and Prof. Dr. Marcus Maurer. By means of structured patient interviews, a list of complaints was initially drawn up using established procedures and in accordance with international recommendations. Using impact and factor analyses as well as by face validity, the 9 most common and most relevant symptoms were selected for the final MAS instrument. The instrument was tested for validity and reliability as well as examined with regard to possible influencing factors.

Quick Facts MAS:
Number of items: 9
Suited for:  All adult (≥ 18 years) patients with cutaneous and indolent systemic mastocytosis
Recall period: prospectively, 14 days
Domains:  Skin, GI tract, other symptoms
Scoring: Domain scores (0 - 100 each) and total score (0 – 100), scoring template available
Copyright: Moxie GmbH (
Terms of use: Free for routine clinical use and non-commercial research, fee requested for use in clinical trials/commercial research.

Siebenhaar F, Sander B, Ho LHT, Ellrich A, Maurer M, Weller K.Development and validation of the mastocytosis activity score. Allergy. 2018 Jul;73(7):1489-1496. doi: 10.1111/all.13425. Epub 2018 Mar 1. PMID: 29405310

Commercial or non-commercial

If you are interested or on request, we will be happy to send you our PROMs (Patient Reported Outcomes Measures) on the various topics by e-mail. 

Please understand that we have to charge a fee of 15 Euro per PRO when using our PROMs for commercial purposes. Commercial use include, for example, use in industry-sponsored studies, market research and similar purposes.

By non-commercial use we mean e.g. use for consultation hours in hospitals and private practices, use within scientific studies without sponsoring. The prerequisite is that no commercial interest is pursued.

Frequently Asked Questions

Why are there PRO (Patient Reported Outcomes) products that cost nothing and others that cost 15 Euros?

If you plan to use PRO (Patient Reported Outcomes) products (e.g. AAS, AE-QoL, UCT) commercially, there is a small fee per patient (15 €). This applies, for example, to industry-sponsored trials and clinical studies or market research.
You can order free versions, if you plan to use them for non commercial purposes, e.g. for patient management or for academia-driven non commercial
research projects. When you order PRO (Patient Reported Outcomes) products, these instruments are sent per e-mail.

I would like to use PRO (Patient Reported Outcomes) products commercially. Do I have to buy one version each for every time I plan to use it, even in the same patient?

No. Each PRO (Patient Reported Outcomes) products you purchase can be used multiple time by the same patient.

What do I do if PRO (Patient Reported Outcomes) products are not available for my country or in the language I need?

The version you are looking for is probably already under development. Feel free to get in touch with us by e-mail to check when it will be available.