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Angioedema Activity Score (AAS)

Angioedema Activity Score (AAS)

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The Angioedema Activity Score (AAS) is a validated, easy to use questionnaire to determine disease activity in patients with recurrent angioedema. It can be used in patients with histamine-mediated, bradykinin-mediated and idiopathic recurrent angioedema. The AAS is designed as a diary-type tool, to be used by patients for a daily documentation of their swelling episodes, including their duration, severity and impact on daily functioning and appearance.

The AAS was developed by a Charité team of scientists led by Dr. Karsten Weller and Dr. Marcus Maurer. Briefly, after a set of potential AAS items was developed, item evaluation and reduction were performed, for example, by means of impact analysis and by checking for face validity. In addition, the items of the final AAS were tested for their validity and reliability during a validation study.

Quick Facts AAS:
Number of items: 6 (on days with angioedema), 1 (on days without)
Suited for: Adults (≥18 years old) with histamine-mediated, bradykinin-mediated and idiopathic recurrent angioedema.
Assessment: prospectively, e.g. 4 weeks
Scoring: sum scoring, scoring template available
Copyright: Moxie GmbH (
Terms of use: Free for routine clinical use and non commercial research, small fee for use in clinical trials/commercial research

Weller K, Groffik A, Magerl M, Tohme N, Martus P, Krause K, Metz M, Staubach P, Maurer M. Development, validation, and initial results of the Angioedema Activity Score. Allergy 2013; DOI: 10.1111/all.12209.

Commercial or non-commercial

If you are interested or on request, we will be happy to send you our PROMs (Patient Reported Outcomes Measures) on the various topics by e-mail. 

Please understand that we have to charge a fee of 15 Euro per PRO when using our PROMs for commercial purposes. Commercial use include, for example, use in industry-sponsored studies, market research and similar purposes.

By non-commercial use we mean e.g. use for consultation hours in hospitals and private practices, use within scientific studies without sponsoring. The prerequisite is that no commercial interest is pursued.

Frequently Asked Questions

Why are there PRO (Patient Reported Outcomes) products that cost nothing and others that cost 15 Euros?

If you plan to use PRO (Patient Reported Outcomes) products (e.g. AAS, AE-QoL, UCT) commercially, there is a small fee per patient (15 €). This applies, for example, to industry-sponsored trials and clinical studies or market research.
You can order free versions, if you plan to use them for non commercial purposes, e.g. for patient management or for academia-driven non commercial
research projects. When you order PRO (Patient Reported Outcomes) products, these instruments are sent per e-mail.

I would like to use PRO (Patient Reported Outcomes) products commercially. Do I have to buy one version each for every time I plan to use it, even in the same patient?

No. Each PRO (Patient Reported Outcomes) products you purchase can be used multiple time by the same patient.

What do I do if PRO (Patient Reported Outcomes) products are not available for my country or in the language I need?

The version you are looking for is probably already under development. Feel free to get in touch with us by e-mail to check when it will be available.